Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process el 19 0.583 0.912 0.767 0.104
biological_process ka 19 0.001 0.372 0.146 0.096
biological_process rf 19 0.002 0.371 0.159 0.096
disease ct 9 0.035 0.697 0.353 0.242
disease el 9 0.113 0.918 0.478 0.272
disease ka 9 0.004 0.662 0.346 0.243
disease rf 9 0.034 0.697 0.354 0.243
genetic_interaction el 17 0.0 0.991 0.595 0.334
genetic_interaction ka 17 0.0 0.817 0.551 0.241
genetic_interaction rf 17 0.0 0.99 0.609 0.315
molecular_function ct 2 0.43 0.637 0.533 0.103
molecular_function el 2 0.407 0.658 0.533 0.126
molecular_function ka 2 0.455 0.637 0.546 0.091
molecular_function rf 2 0.43 0.636 0.533 0.103
pathway ct 19 0.001 0.901 0.491 0.299
pathway el 19 0.001 0.793 0.412 0.294
pathway ka 19 0.001 0.955 0.474 0.357
pathway rf 19 0.001 0.785 0.387 0.268
phenotype ct 7 0.007 0.609 0.402 0.25
phenotype el 7 0.085 0.561 0.32 0.181
phenotype ka 7 0.006 0.655 0.426 0.268
phenotype rf 7 0.007 0.609 0.402 0.25
protein_interaction ct 19 0.002 0.4 0.16 0.11
protein_interaction el 19 0.003 0.258 0.091 0.07
protein_interaction ka 19 0.002 0.982 0.602 0.366
protein_interaction rf 19 0.002 0.386 0.149 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 19 0.001 0.984 0.552 0.43
integration_mean_by_presence el 19 0.0 0.797 0.23 0.228
integration_mean_by_presence ka 19 0.0 0.547 0.247 0.173
integration_mean_by_presence rf 19 0.0 0.857 0.301 0.284
mean ct 19 0.0 0.987 0.555 0.433
mean el 19 0.0 0.368 0.101 0.11
mean ka 19 0.0 0.377 0.131 0.116
mean rf 19 0.0 0.386 0.119 0.118

CDF plots of non integrated kernels

CDF plots of integrated kernels