Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	el	19	0.583	0.912	0.767	0.104
biological_process	ka	19	0.001	0.372	0.146	0.096
biological_process	rf	19	0.002	0.371	0.159	0.096
disease	ct	9	0.035	0.697	0.353	0.242
disease	el	9	0.113	0.918	0.478	0.272
disease	ka	9	0.004	0.662	0.346	0.243
disease	rf	9	0.034	0.697	0.354	0.243
genetic_interaction	el	17	0.0	0.991	0.595	0.334
genetic_interaction	ka	17	0.0	0.817	0.551	0.241
genetic_interaction	rf	17	0.0	0.99	0.609	0.315
molecular_function	ct	2	0.43	0.637	0.533	0.103
molecular_function	el	2	0.407	0.658	0.533	0.126
molecular_function	ka	2	0.455	0.637	0.546	0.091
molecular_function	rf	2	0.43	0.636	0.533	0.103
pathway	ct	19	0.001	0.901	0.491	0.299
pathway	el	19	0.001	0.793	0.412	0.294
pathway	ka	19	0.001	0.955	0.474	0.357
pathway	rf	19	0.001	0.785	0.387	0.268
phenotype	ct	7	0.007	0.609	0.402	0.25
phenotype	el	7	0.085	0.561	0.32	0.181
phenotype	ka	7	0.006	0.655	0.426	0.268
phenotype	rf	7	0.007	0.609	0.402	0.25
protein_interaction	ct	19	0.002	0.4	0.16	0.11
protein_interaction	el	19	0.003	0.258	0.091	0.07
protein_interaction	ka	19	0.002	0.982	0.602	0.366
protein_interaction	rf	19	0.002	0.386	0.149	0.104

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Min	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	19	0.001	0.984	0.552	0.43
integration_mean_by_presence	el	19	0.0	0.797	0.23	0.228
integration_mean_by_presence	ka	19	0.0	0.547	0.247	0.173
integration_mean_by_presence	rf	19	0.0	0.857	0.301	0.284
mean	ct	19	0.0	0.987	0.555	0.433
mean	el	19	0.0	0.368	0.101	0.11
mean	ka	19	0.0	0.377	0.131	0.116
mean	rf	19	0.0	0.386	0.119	0.118

CDF plots of non integrated kernels

CDF plots of integrated kernels